Yearly Archive

Yearly Archives: 2014

June 26, 2014 no comments

“On the way to changing the world, there are no signposts” : the illusory power of precedents

Precedents play a central role in the drug development industry.  Clinical trials are based on earlier studies with ostensibly similar drug candidates.  Business models are judged against the current landscape.  Assets are valued by looking for comparables.  Indeed, big pharma consider the institutional accumulation of such experience to be a significant competitive advantage.


But if you stop and think about it, such an approach makes no sense if you seek true innovation.  The premise of all innovation is that it breaks the mould, changes the goalposts, disrupts the marketplace.  Aiming to change the world, and then judging your progress against historical norms isn’t just meaningless – some precedents can lead you down blind alleys or drive altogether the wrong decisions.


DrugBaron examines a number of recent examples of misapplied precedents to illustrate why, when searching for the breakthrough that changes everything, forwards is the only way to look.



June 2, 2014 no comments

Cometh the saviour? Casting Valeant’s J. Michael Pearson in a new role

There has been much written about the proposed …

December 10, 2013 comments

Monte Carlo models of drug R&D focus attention on cutting costs – Part 1

There is a theme behind many of DrugBaron’s …

December 9, 2013 comments

Monte Carlo models of drug R&D focus attention on cutting costs – Part 2 (the caveat!)

“So DrugBaron tells me that drug discovery and …

October 24, 2013 comments

Evidence that “pick the winners” is precisely the wrong strategy

The asset-centric platform at Index Ventures is built …

September 9, 2013 comments

Asset-centric project financing is AN answer – not THE answer

As In Vivo blog noted last week, asset-centric …

June 17, 2013 no comments

Ichorcumab: the blood of the gods?

Index Ventures have announced the completion of an …

June 10, 2013 comments

Did I say asset-centric? I meant team-centric!

In many Buddhist traditions there is a dislike …

April 8, 2013 no comments

The power of crowds – and their limits

The first internet revolution in the 1990s saw …

February 28, 2013 comments

Venture Capital 2.0

Innovation is the life-blood of venture capital.  Whether …


Yearly Archive