Yearly Archive

Yearly Archives: 2013

July 31, 2013 comments

The zero person biotech company

Comparing the founding of two virtual drug development companies, Funxional Therapeutics in 2006 and XO1 earlier in 2013 proves at least one thing: in just seven years it has become dramatically easier and quicker to create a virtual drug development company.  Today it is even possible to take virtual to its logical extreme: a zero person biotech company.

Given there is nothing inside a virtual company except for an asset, how can setting up and running an empty husk have changed so dramatically in under a decade?

The answer lies in what’s outside, not inside, the virtual development company.  Today, a whole ecosystem of service providers exist to facilitate every facet of virtual drug development.  And these providers have evolved and optimized their services to such an extent that they are barely recognizable.

In 2006, the service ecosystem consisted almost exclusively of Contract Research Organisations (CROs).  Large or small, these CROs tend to be very good at what they do and very poor at everything else.  Hence, when a project demands real innovation it is almost impossible to deliver in virtual mode with only CROs to help.

But by 2013, the emergence of true Out-Sourced Drug Developers (ODDs) have changed the equation firmly in favour of virtual development for almost every kind of drug candidate.  Virtual no longer implies a lack of quality, nor a lack of scalability.

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July 16, 2013 comments

Incremental innovation lives on

In 2010, DrugBaron declared the death of incremental …

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June 24, 2013 no comments

Positive publication bias IS harmful

DrugBaron was intrigued to see a paper published …

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June 17, 2013 no comments

Ichorcumab: the blood of the gods?

Index Ventures have announced the completion of an …

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May 22, 2013 no comments

How NOT to cut costs

DrugBaron’s mantra is simple: drug development is too …

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March 19, 2013 no comments

Biosimilars are not similar enough: A proposal for true ‘biogenerics’

As the debate rumbles on about biosimilars, DrugBaron …

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February 11, 2013 no comments

The Primacy of Statistics: In defense of the pivotal Phase 3 Clinical Trial

Statistics have always had a bad press.  Ever …

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January 29, 2013 comments

The REAL scandal of drug pricing

Healthcare provision, at least in the Western world, …

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January 14, 2013 no comments

Why hubris kills returns on pharma R&D

On January 11th, David Shaywitz (@DShaywitz) posted an …

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January 7, 2013 no comments

The 39 (mostly small) Steps: The Class of 2012 FDA Approvals

The pharmaceutical industry achieved 39 approvals in 2012 …

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