A new study suggests that factor Xa inhibitors, such Eliquis™ apixaban from BMS and partner Pfizer, can be superior to warfarin.  On a composite efficacy end-point in atrial fibrillation patients apixaban was significantly better than warfarin (1.3% versus 1.6%; p<0.01), while bleeding side-effects and death from any cause were both significantly improved, according top data from the vast 18,000 patient ARISTOTLE trial announced at the European Society for Cardiology meeting in Paris.

This is in marked contrast to the results published in the New England Journal of Medicine (365:699-708), also in August 2011, showing that apixaban increased bleeding episodes without reducing cardiovascular events in patients with acute coronary syndromes.More

RxCelerate Ltd is an outsourced drug development platform based near Cambridge, UK. We specialize in delivering an entire road map of drug development services from discovery and medicinal chemistry through to formal preclinical development and clinical up to Phase IIa. In the last five years, we have witnessed dramatic changes in the drug development …